EFFICACY OF THROMBOLYTIC THERAPY WITH STREPTOKINASE IN DIABETIC AND NON-DIABETIC PATIENTS AGED 40-70 YEARS PRESENTING WITH ACUTE ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION IN TERTIARY CARE HOSPITALS KPK PESHAWAR.
DOI:
https://doi.org/10.64105/3tq49r82Abstract
Background: Myocardial infarction is one of the most prevalent types of coronary artery disease. It is the leading cause of mortality and morbidity worldwide. Myocardial infarction is classified into two types based on ECG findings that are ST ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (ASTEMI). Among the risk factors for myocardial infarction, diabetes mellitus is one of the major factors showing a strong association with myocardial infarction.
Objectives: This study was conducted to study how diabetes mellitus affects the efficacy of streptokinase used for thrombolysis in a tertiary care hospital (STH Swat and LRH Peshawar).
Methods: This study was conducted in the Institute of Paramedical Sciences (KMU), Peshawar, and the Cardiology department of Tertiary Care Hospitals (Saidu Teaching Hospital and Lady Reading Hospital). The research was carried out from June to November 2023. (6 months). This Descriptive cross-sectional study was conducted using a predesigned self-structured questionnaire. The gathered data were analyzed through SPSS version 22.
Result: Total 166 patients were studied n= 68(40.96%) were diabetic and n=98(59.0%) were non diabetics. Among the diabetics n=51(75%) streptokinase shows less than 50% depression and n=17(25%) shows greater than 50% depression. Among the non-diabetic n=70(71.4%) streptokinase shows Greater than 50% depression and n=28(28.5%) shows less than 50% depression. So the effectiveness of streptokinase in diabetics was 25% and those in non-diabetics were 71.4 %. Chi-square test shows a p-value of <0.001, which shows a significant difference between the efficacy of streptokinase in diabetic and Non diabetic patients.
Conclusion: This study shows that the efficacy of streptokinase in diabetic patients presenting with acute ST elevation myocardial infarction is less than in non-diabetic patients presenting with acute ST elevation myocardial infarction.
