PREVALENCE OF PREDIABETES AND INSULIN RESISTANCE AMONG WOMEN WITH POLYCYSTIC OVARY SYNDROME

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is a widespread endocrine condition marked by major metabolic anomalies, especially insulin resistance and inability to regulate glucose levels. Pediatric prediabetes diagnosis is crucial to avoid the development of type 2 diabetes mellitus and associated problems in this group of the population.

Objective: To establish the prediabetes and insulin resistance prevalence and relationship in women with PCOS and to determine their correlations with clinical, anthropometric and biochemical outcomes.

Material & Methods: Cross-sectional descriptive study was done on 150 women diagnosed with PCOS according to the Rotterdam criteria. The assessments of glycemic status were conducted in terms of fasting blood glucose (FBG), 2-hour oral glucose tolerance test (OGTT), and HbA1c. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) was used to assess insulin resistance. Data analysis was done using SPSS and p<0.05 was taken as the statistical significance.

Results: The prediabetes and type 2 diabetes were 30.7 and 8.0 percent, respectively. 65.3% of the participants had insulin resistance (HOMA-IR > 2.0). Insulin resistance was also significantly correlated with BMI (p<0.001) with a prevalence of 47.4% among normal-weighted individuals and 86.7% among the obese individuals. There were strong positive relationships between HOMA-IR and HbA1c (r=0.73), FBG (r=0.68), and OGTT (r=0.71). OGTT was the most accurate in diagnosis (AUC=0.92), whereas combined screening methods demonstrated the best results (AUC=0.95).

Conclusion: Pre-diabetes and insulin resistance are quite common among women with PCOS. Timely identification and intervention of long-term complications are possible only through early and thorough metabolic screening with integrated diagnostic methods.