EFFECT OF VITAMIN D SUPPLEMENTATION ON THYROID FUNCTION TESTS IN HYPOTHYROID PATIENTS: A SIX-MONTH STUDY AT PAKISTAN EMIRATES MILITARY HOSPITAL RAWALPINDI

Abstract

Objectives: To evaluate the impact of vitamin D supplementation on thyroid function tests in patients with hypothyroidism attending the Family Medicine outpatient department at Pakistan Emirates Military Hospital Rawalpindi. Study Design: A prospective interventional study. Place & Duration: Pakistan Emirates Military Hospital Rawalpindi; six months after approval of the topic, from June, 7 2023 to November, 7 2023. Methodology: One hundred adult patients with diagnosed hypothyroidism were enrolled. Participants received weekly oral vitamin D supplementation (50,000 IU) for 12 weeks. Thyroid function tests, including serum TSH, T3, T4, and 25-hydroxyvitamin D (25(OH)D) levels, were measured at baseline and after 12 weeks. Results: After 12 weeks, there was a significant decrease in serum TSH levels (mean reduction of 0.4 μIU/mL, p < 0.05) and a significant increase in 25(OH)D levels (mean increase of 26.5 ng/mL, p < 0.001). No significant changes were observed in T3 and T4 levels. Conclusion: Vitamin D supplementation in hypothyroid patients led to a significant reduction in TSH levels and an increase in 25(OH)D levels, suggesting a potential role of vitamin D in modulating thyroid function.

Key Words: Vitamin D, Hypothyroidism, Thyroid Function Tests, TSH, 25-Hydroxyvitamin D