Emerging trends and role of biologically active metalloproteinases enzymes

Abstract

Limb model is used to explain the mechanism of regeneration in axolotl. This model is based on classic studies demonstrating that an entire limb can be induced to form on the side of the arm when appropriate signals from nerves and connective tissues, fibroblasts are provided. The unique ability of amphibians to regenerate whole limbs demonstrates a greater capacity for regeneration and healing when compared with wound healing in mammals. Regeneration of amputated digits has been documented in higher-order mammals in the embryonic and neonatal stages. MMP7 also suggested to have a possible role in postinfarction angiogenesis, as demonstrated by plasminogen activation by increased secretion of urokinase-type plasminogen activator, which is known to degrade basement proteins and activate growth factors involved in angiogenesis. MMPs contribute to the digit or limb regeneration by promoting ECM degradation and the formation of the wound epidermis, which is formed by the migration of epidermal cells to the perimeter of the amputation surface and is necessary for wound closure.