PREPARATION AND ASSESSMENT OF PHARMACEUTICAL HYDROGELS OF CIPROFLOXACIN BY USING POLYMERS

Abstract

The main goal of this assessment was to create pH-responsive hydrogels formulation using polymers. For the controlled distribution of Ciprofloxacin (CPX), which is intended for release in the duodenum, hydrogels formulations were created. Formulations that have been evaluated in vitro for their chemical compatibility with the loaded drug, gel-matrix morphology, swelleability, and drug release kinetics. All of the formulations offered swelleability and pH-dependent drug release. With a very low quantity of the drug releasing at the pH equivalent to that of stomach pH, designing was based on a blend of derived and natural polymers, demonstrated prolonged stable drug release at the pH of the duodenum. Diffusion was the main methods that contributed to the release of drugs. FTIR study showed no drug-gel interaction, and SEM analysis showed that the gel matrix had a porous surface with linked tunnels. The interconnected tunnel structure may contribute to the diffusion of drug molecules and aqueous media. This assessment confirmed about hypothesis demonstrated on the development of pH-responsive extended release of drug delivery system for the hydrophilic and the lipophilic drugs as well, benefited greatly from the use of both natural and synthetic gum, the small intestine being the primary site of absorption. Future studies should concentrate on pharmacokinetic profiling and cytotoxic analysis of drugs loaded in pH-responsive hydrogels.