Time And Factors Associated With Rapid Worsening Of Renal Functioning In Chronic Kidney Disease Patients At A Tertiary Care Hospital In Quetta

Abstract

Background: Chronic kidney disease (CKD) is characterized by a progressive decline in kidney function leading to the development of substantial morbidity and mortality, especially in a resource-poor country like Pakistan. Acknowledging the factors associated with a rapid decline in renal function will be domain of focus in a patient outcomes-improving cycle which will facilitate early spotting of those susceptible groups.

Objective: The goal of this study was to examine the duration and predictors of early deterioration of renal function in people with CKD at a tertiary care facility in Quetta.

Methods: This was a retrospective cohort study at Balochistan Institute of Nephro-Urology, Quetta including 271 patients of chronic kidney disease stage 3 and 4. We extracted data from medical records concerning socio-demographic, clinical, laboratory, and treatment characteristics. Decline in eGFR, increase in serum creatinine, doubling of creatinine, and CKD stage progression were used as definitions of early worsening of renal function. Associations were analysed using chi-square tests and were considered significant at p 0.05).

Conclusion

In conclusion, progression of CKD with important clinical impact is not uncommon in this population, with unacceptably poor control of comorbid conditions despite demographic and behavioral risk factors. In CKD patients, to prevent disease progression and improve outcomes, it is essential to detect early, manage diabetes and hypertension better, and achieve more structured follow-up.