Dual Drug Loaded Nanoparticles For Enhanced Pain Relief And Anti-Inflammatory Actions

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) and steroidal anti-inflammatory drugs (corticosteroids) are curative management regimen for alleviating pain and anti-inflammatory effects. The aim of study was to create a novel dual-drug of NSAID-corticosteroid encapsulated into chitosan (CS) nanoparticles to increase their solubility, attain a sustained release system and reduce systemic adverse effects. The ionic gelation method, which provides a mild and effective way for drug encapsulation, was utilized to create naproxen-dexamethasone (nap-dex) loaded chitosan nanoparticles (CNPs). Nap-dex loaded CNPs were defined by UV-Visible spectrophotometry, zeta size, scanning electron microscope (SEM) and fourier transform infrared spectroscopy (FTIR). Zeta size analysis identified nanoparticles with an adequate size and stability for drug delivery, while the UV and FTIR spectra confirmed successful drug loading and interaction with the chitosan matrix. SEM analysis revealed a spherical shape with smooth surface properties. In vitro drug release study was done by using dialysis membrane method revealing a sustained and controlled release profile of the dual drug. T-test confirmed that all pairwise comparisons between time intervals were statistically significant (p < 0.05). The prepared nano dual drug is a novel therapy that showed a sustained release profile and enhanced bioavailability with an excellent anti-inflammatory activity