Comparison Of Pre-Operative And Post-Operative Liver Profile In Patients Undergoing Cardiopulmonary Bypass: Correlation With Post-Operative Recovery
DOI:
https://doi.org/10.66021/pakmcr1440Keywords:
CPB (Cardiopulmonary Bypass), LFTs (Liver Function Test), ALT (Alanine Aminotransferase), AST (Aspartate Aminotransferase), ALP (Alkaline Phosphatase), INR(International Normalized Ratio), ICU (Intensive Care Unit)Abstract
Background: Cardiopulmonary bypass is a lifesaving technique during heart surgery, but it can disturb normal blood flow and provoke inflammation, which also affects the liver. Changes in liver function profiles can, in turn, impact the recovery period and complication rates. This study showed changes in liver profile before and after CPB and how these changes influenced postoperative recovery outcomes and complications.
Methodology: This was a cross-sectional observational study. Data was collected from 150 patients undergoing cardiopulmonary bypass preoperatively and postoperatively. A pre-structured questionnaire was used to collect data from two different cardiac centers, based on predefined inclusion criteria.
Results: After cardiopulmonary bypass, liver function tests showed clear changes. AST, ALT, bilirubin, and INR increased, while albumin decreased, showing temporary liver stress. Patients who developed liver dysfunction stayed longer in the ICU, needed ventilation for longer hours, and had longer hospital stays. Longer CPB time, cross-clamp time, and low blood pressure during surgery were linked with impair liver function.
Conclusion: Cardiopulmonary bypass can cause short-term liver injury that affects patient recovery. Early monitoring of liver tests and good control of blood pressure and CPB time can help reduce complications and improve outcomes after cardiac surgery.
