Demographic And Lifestyle Correlates of Serum Uric Acid Levels among Patients in Khairpur Mir’s, Sindh

Abstract

Hyperuricemia is a clinical position related to metabolic syndrome, cardiovascular and gout pathologies, mostly provoked by modern daily life shifts. Unlike most mammals, humans lack a functional uricase enzyme to degrade uric acid further into allantoin. This study aimed to investigate the prevalence of normal and abnormal serum uric acid levels across different age groups, genders, dietary profiles, and physical activity tiers within the population of Khairpur Mir's. A descriptive cross-sectional study was conducted involving 169 randomly selected individuals. Dietary and activity profiles were evaluated using an administered lifestyle questionnaire. Serum uric acid was determined spectrophotometrically utilizing an enzymatic uricase-based protocol at 293 nm. Data were processed using Microsoft Excel and SPSS version 24. Of the 169 subjects, 50.3% were male and 49.7% were female. Females exhibited a higher overall hyperuricemic prevalence (13.0%) compared to males (10.1%). Age-stratified breakdown showed that the highest concentration of abnormal levels occurred within the 51–70 age group, affecting 53% of females and 30% of males in that tier. While omnivorous diets correlated with high baseline patient numbers, vegetarian males surprisingly demonstrated a 50% hyperuricemia rate within their small cohort. Crucially, subjects reporting zero physical activity demonstrated significantly elevated risks of abnormal uric acid levels. Advanced age, female gender post-menopausal status and sedentary lifestyles are strong risk factors for hyperuricemia in the target population. Public health campaigns focusing on physical mobilization and dietary regulation are essential to prevent secondary metabolic illnesses.