Schiff Base Derivative of Aldehydes with Diamino Compound and their Anti-Inflammatory Activity

Abstract

A Schiff base is a ketone or aldehyde nitrogen analog in which the group between carbon and oxygen is substituted by the group C = N -R. Schiff’s bases are commonly used compounds which interrelate through azomethine nitrogen with metal ions and they have applications in many fields including biological, analytical and inorganic chemistry. Schiff’s bases are used in organic synthesis as coloring agent, as catalysts, as intermediates and also as polymer stabilizer. Schiff bases also exhibited anti-inflammatory activities. Bis-salicaldihyde synthesized using methanolic solution of salicylaldehyde which was reacted with ethylene diamine for 15 minutes at room temperature. The resulting compound was then characterized by melting point and pharmacological activities were done. Acute toxicity of the compound was also carried out. Studies were performed on albino mice on three different doses (50, 100 and 150 mg).Results revealed that bis-salisaldehyde have no toxicity upto 1000 mg dose, and have anti-inflammatory effects.