Impact Of Nicardipine, A Calcium Channel Blocker, On Renal Function And Systolic Blood Pressure
DOI:
https://doi.org/10.5281/zenodo.20495817Keywords:
Nicardipine, Hypertensive Crisis, Systolic Blood Pressure, Renal Function, GFRAbstract
Background: Rapid but controlled blood pressure lowering is necessary to prevent end-organ damage, especially renal impairment, in hypertensive crisis, a potentially fatal condition. Because of its good hemodynamic profile and titratable IV administration, nicardipine, a calcium channel blocker, is frequently utilized.
Objective: To evaluate the effect of nicardipine on systolic blood pressure and renal function parameters in patients presenting with hypertensive crisis.
Methodology: Patients at a tertiary care hospital in Lahore who were receiving intravenous nicardipine for blood pressure control participated in an observational study. Clinical and demographic information was documented. Prior to and following therapy, SBP and renal function parameters were measured, including serum creatinine, glomerular filtration rate(GFR), blood urea nitrogen (BUN), urine albumin-to-creatinine ratio, urea, and urine output. Data were analyzed by SPSS V-26 using paired sample t-tests to determine the significance of changes.
Results:SBP was found to have significantly decreased from 160.45±9.60 mmHg to 129.90±10.20 mmHg(p < 0.001). DBP also dropped from 92.04±4.64 mmHg to 75.90±5.10 mmHg(p < 0.001). From 2.172±0.893 mg/dL to 2.194±0.895 mg/dL, serum creatinine increased slightly but statistically significantly (p = 0.010). Urine production, on the other hand, increased dramatically from 0.956±0.165 to 1.056±0.170 mL/kg/hour(p<0.001), suggesting greater renal perfusion.
Conclusion: Nicardipine is an effective and safe agent for rapid blood pressure reduction in hypertensive crisis, with minimal adverse effects on renal function. Its use may be considered beneficial in clinical settings requiring precise blood pressure management without compromising renal integrity.
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