COMPUTATIONAL MODELING OF DIAMOND NANOPARTICLES FOR HYPERTHERMIA INDUCED CANCER THERAPY

Abstract

Cancer is one of the most consequential causes of death worldwide. New treatment approaches must be developed for the disease. The continuous improvement of early diagnoses has not yet wholly freed chemotherapy from the effects of resistance, tumor heterogeneity, and systemic metastasis. Illnesses usually immune to chemotherapy, radiotherapy, or immunotherapy are, therefore, being studied to improve the effectiveness of treatment and warrant high quality of life for their patients in many complementary and alternative studies. Hyperthermia therapy raises the temperature of cancerous tissues to an elevated level (physically at about 41-45 degrees centigrade). It is famous as one of the high promises adjuvants to the conventional therapies it co-administers. Hyperthermia, which causes thermal damage to tumor cells, improves the therapeutic potential of chemotherapy and radiotherapy and occasionally results in fast death, which is immediate, of cancer cells. The core mechanism of hyperthermal cytotoxicity is thermal stress, which leads to the denaturation of proteins, disruption of membranes, damage of the cytoskeleton, and finally, to apoptosis. It also has several other mechanisms to improve cancer treatment from hyperthermia, such as stimulating specific immune responses and increasing permeability of the drugs. However, the most significant drawback is related to localized and accurate heating without the distal healthy tissue getting affected (Jha, Sharma, & Malviya, 2016).