Role of Non-Invasive Ventilation in Respiratory Failure due to Poor Treatment Compliance in Chronic Obstructive Pulmonary Disease Patients

Abstract

Objective: To determine the efficacy of non-invasive ventilation in respiratory failure due to poor treatment compliance in COPD patients. Study Design: Quasi experimental study. Place and Duration of Study: This study was carried out in the Department of Pulmonology at Medical Teaching Institution Hayatabad Medical Complex Peshawar from 25 July 2025 to 25 January 2026. Methodology: A total of 110 patients having age between 30 and 70 years with respiratory failure due to poor treatment compliance in chronic obstructive pulmonary disease were included. All patients were managed with non-invasive ventilation and arterial blood gas was repeated after 24 hours. Efficacy was noted. Data analysis was done using Statistical Package for Social Sciences version 25. Mean and standard deviation were calculated for numerical variables and frequencies with percentages for categorical variables. Chi-square test were applied for stratification. Results: Mean age of patients was 53.05 ± 10.06 years and mean body mass index was 28.22 ± 3.31 kilograms per square meter. There were 76(69.1%) males and 34(30.9%) females. Overall efficacy of non-invasive ventilation was observed in 66(60.0%) patients while 44(40.0%) patients did not show improvement. No significant association was found between efficacy and demographic factors including age, gender, body mass index, smoking, diabetes, hypertension, profession and previous ventilation history (p>0.05). Conclusion: Non-invasive ventilation shows moderate effectiveness in management of respiratory failure among patients with chronic obstructive pulmonary disease who have poor treatment compliance.

Keywords: Chronic Obstructive Pulmonary Disease; Pulmonary Ventilation; Respiratory Insufficiency; Treatment Outcome