Neurodegenerative Diseases: Current Understanding and Future Directions

Abstract

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS), represent a growing global health crisis as the elderly population expands. These disorders are characterized by the progressive loss of specific neuronal populations, often associated with protein misfolding and aggregation. This review synthesizes current understanding regarding common pathophysiological hallmarks, such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. We evaluate recent advancements in diagnostic biomarkers, including PET imaging and fluid-based proteomic signatures, and discuss the shift from symptomatic to disease-modifying therapies. Furthermore, this paper explores the emerging role of the gut-brain axis and artificial intelligence in personalized neurology. By identifying current gaps in clinical translation, we outline future directions for therapeutic intervention, emphasizing the necessity of multi-modal treatment strategies.