Therapeutic Potential of Deep Eutectic Mixture-Based Nanofluids in Wound Healing and Anti-aging Agents: A Systematic Review

Abstract

Deep eutectic mixtures, frequently described as deep eutectic solvents, natural deep eutectic solvents, or therapeutic deep eutectic systems, have emerged as multifunctional platforms in pharmaceutical, cosmetic, and biomedical delivery. Their relevance to wound healing and anti-aging therapy is based on their capacity to improve solubility, enhance skin permeation, stabilize unstable active compounds, support antimicrobial activity, and integrate with nanocarriers, hydrogels, eutectogels, and topical emulsions. This systematic review evaluates the therapeutic potential of deep eutectic mixture-based nanofluids and related nanoscale systems in wound healing and anti-aging applications. Evidence from preclinical wound models, antimicrobial studies, hydrogel dressings, and retinol-based anti-aging systems indicates that these platforms may improve tissue repair, reduce microbial burden, enhance collagen-related activity, suppress oxidative stress, and improve topical tolerability. Menthol–fatty acid therapeutic deep eutectic systems have shown antibacterial and wound-healing effects, while linolenic acid–phosphatidylcholine deep eutectic emulsion systems have improved retinol stability, skin permeation, anti-wrinkle activity, hydration, collagen intensity, and irritation profile. Despite this promise, clinical translation remains limited by inconsistent terminology, insufficient long-term toxicology, variable formulation design, and limited human studies. Overall, deep eutectic mixture-based nanofluids represent a promising but still developing class of therapeutic systems for wound repair and skin anti-aging.

Keywords: Deep eutectic solvent, therapeutic deep eutectic system, nanofluid, wound healing, anti-aging, hydrogel, eutectogel, retinol, topical delivery