Comparative Evaluation Of Propofol Vs Ketamine On Intraoperative Hemodynamic Stability In Patients Undergoing Perforated Laparotomy

Abstract

Background: Intraoperative hemodynamic stability is of great importance in emergency patients like perforated laparotomy. Type of anesthetic induction is of critical importance in the shaping of responses of the heart. Propofol has been widely adopted and is linked to hypotension, but ketamine ensures cardiovascular stability by its sympathomimetic action.

Objective: The aim of the study was to evaluate the impact of propofol and ketamine on intraoperative hemodynamic stability in perforated laparotomy patients.

Methodology: Cross-sectional research was carried out in two tertiary care hospitals in Lahore involving 80 patients who were divided into two groups: ketamine (Group A) and propofol (Group B). The information about the demographic features, intraoperative hemodynamic variables, challenges, postoperative hypotension, adverse effects, and patient satisfaction was gathered and examined on the basis of SPSS.

Results: Ketamine was found to be more hemodynamically stable, there was less postoperative hypotension (22.5% vs 27.5) and reduced postoperative side effects. Propofol on the contrary had fewer intraoperative complications (17.5% vs 27.5) and more easily induced and a better intraoperative stability. The satisfaction of the patients and recommendations were better in the ketamine group. 

Conclusion(s): They are both effective nonetheless, ketamine is effective in hemodynamically unstable conditions which are better than propofol in healthy conditions, since it induces more smoothly.