The Silent Collapse: Unrevealing a Hidden Pediatric ThreatA Case Report on Haemolytic Uremic Syndrome (HUS): A 9-Year-Old Female Patient

Abstract

A 9-year-old female patient presented with high-grade fever, altered consciousness, seizures, thrombocytopenia, and acute kidney injury. Her clinical condition progressively deteriorated, with worsening renal dysfunction, neurological manifestations, and complications during hospitalization. The clinical findings were suggestive of a thrombotic microangiopathic process, and atypical hemolytic uremic syndrome (aHUS) was suspected after evaluation for other possible causes. The patient required intensive care, mechanical ventilation, haemodialysis, and plasmapheresis. Despite aggressive supportive and therapeutic management, her condition continued to worsen. She developed gastrointestinal bleeding and severe cardiovascular instability during the prolonged intensive care stay. After 38 days of hospitalization, the patient developed cardiac arrest and could not be successfully resuscitated. This case highlights the severe clinical course, diagnostic challenges, and potentially fatal outcome of suspected aHUS in a paediatric patient.