THE PREVALENCE OF BIOCHEMICAL PATTERN IN MINERAL BONE DISEASE AMONG HEMODIALYSIS PATIENTS

Abstract

Background:

Mineral  homeostasis gradually weeakens as the function of kidney declines,with disturbance in normal phosphorus and calcium concentrations in serum and  tissue,with the addition of the variations in hormone levels in blood including PTH,  fibroblast growth factor-23 , and clcitriol(1,25(OH)2D).

Objectives:

To determine the pravelance of biochemical pattern of mineral bone disease among hemodialysis patients and comparing the biochemical pattern of mineral bone disease between public and private hospitals.

Methodology:

A Cross-sectional study executed at two hospitals (Ali Fatima Hospital and Chaudhri Muhammad Akram Teaching Hospital ,Lahore ) between January and April 2026. 70 patients who had been on long term hemodialysis for more than three months were slected using targeted sampling. With the help of an interviewer-administered questionnaire, the demographic profile and clinical features of the patients were recorded. Before dialysis blood samples were analyzed for serum calcium, phosphorus, iPTH, vitamin D, albumin, and ALP.

Result:

50 out of 70 patients had MBD prevalance of 71.4%. The most common disorder was hyperphosphatemia (57.1%) which was followed by vitamin D low levels (55.7%) , hypocalcemia (51.4%), and raised iPTH (50.0%) . Patients in public health care had biochemical profiles that were significantly worse than those in private health care (p<0.05). MBD had no association with dialysis vintages.

Conclusion:

Pattern of MBD was more worse in public sector rather than private sector .Hypertensivenephropathy was  more dominant and hyperphosphatemia seen the most frequent abnormality among pakistani hemodialysis patients with mineral bone disease.There is an urgent requirments for enhanced tracking, and locally adapted treatment protocols.