ROLE OF TWO DIFFERENT BIOCOMPATIBLE COATED CPB CIRCUITS AND ITS IMPACT ON POSTOPERATIVE LEUKOCYTIC COUNT IN PATIENTS WITH CABG

Abstract

Background: Cardiopulmonary bypass (CPB) triggers a profound inflammatory reaction from contact of blood with artificial surfaces, the activation of leukocytes and other inflammatory processes. Biocompatible coatings such as phosphorylcholine and balanced polymer have been used to minimise this.

Objective(s): To compare the impact of two types of biocompatible coated CPB circuits on postoperative levels of leukocytes in patients undergoing coronary artery bypass grafting.

Methodology: In this study, one hundred patients were scheduled for elective coronary artery bypass graft surgery. The study participants were split into two groups according to the type of coating applied to the CPB circuit: balanced coated circuits and phosphorylcholine coated circuits. Demographic and operative details and leukocyte count were measured before surgery, immediately after surgery and at seventy-two hours after surgery. Data was analyzed to compare the results of the two groups.

Results: There was an elevation in the leukocyte count in both groups after surgery, reflecting the inflammatory response due to CPB. But the 72 hours postoperative leukocyte count was significantly greater in the phosphorylcholine group than in the balanced coating group. There was no significant difference in the immediate postoperative leukocyte count. Demographic and operative data were similar between both groups, suggesting similar patient populations.

Conclusion(s): Postoperative leukocytic response is lower in balanced coated CPB circuits than phosphorylcholine coated circuits, especially in the late postoperative period. This study highlights the increased biocompatibility of the balanced coating and its impact on the clinical outcomes for CABG surgery.